I recently performed am IISRESET on some production Azure cloud servers and found to my horror that the website died. A restart resolved the issue, but I had just discovered a little too late that IISRESET is not an option on a Cloud Services server.
This blog (http://www.morestuffabout.net/2012/01/game-over-on-azure-dont-iisreset/) explains some of the alternative options, such as using a utility called ASPRESET which you can find info about at ASPRESET – Jon Galloway blog. This can help avoid needing to do an IISRESET.